Category: Nephrology and Hematology

TGlobulin25, produced by Kowsar Biotech Company, is a rabbit anti-human thymocyte immunoglobulin, the mechanism of action of which is to kill human T lymphocytes, thereby reducing the number of lymphocytes and weakening the immune system.

TGlobulin25 is a lyophilized powder consisting of human immunoglobulin G against human thymocytes at a concentration of 25 mg in each vial. The vials of this drug are dissolved in 5 ml of distilled water and infused with 0.9% sodium chloride.

General Information

TGlobulin25 indications:

This product is used for prophylaxis of acute transplant rejection, treatment of acute rejection (kidney, lung, heart and other organs), aplastic anemia, prophylaxis of transplant disease against acute and chronic host.

More About TGlobulin25

You should know about TGlobulin25:

This product should only be used by physicians who have experience with immunosuppressive drugs for the treatment of transplant patients. TGlobulin25 should be stored in the refrigerator (at 2 to 8 ° C) to prevent freezing.

Dosage Form of TGlobulin25™:

TGlobulin25TM is supplied for injection as a single-dose -5ml vial containing 25 mg of rabbit anti-thymocyte globulin (ATG) sterile lyophilized powder intended for reconstitution prior to intravenous administration.

Administration of TGlobulin25™:

IV: Infuse the first dose over at least 6 hours; subsequent doses may be infused over at least 4 hours. Infuse through a high-flow vein (CV Line). Reducing the infusion rate may minimize infusion reactions. Infusion rate may vary for off-label uses refer to specific protocol

Premedication of TGlobulin25™:

Premedication with corticosteroids, acetaminophen, and/or an antihistamine 1 hour prior to infusion may reduce the incidence of severity of infusion-related reactions. Reducing the infusion rate may minimize infusion reactions.

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